Saturday, August 31, 2019

Parker Pen

Parker Pen: An Adventure in Globalization pg. 547 1. -This is the history of the failure of an international marketing strategy. Which were the reasons? Analyze the 4 P’s. (Price, Product, Place, Promotion) Being one of the largest pen industries in the world, Parker Pen was a failure for having international marketing strategy. This is due to the fact that Parker wanted its products to fall under the concept of standardization. He called this the â€Å"Janesville strategy†. Under promotion, Parker Pen wanted his pens to follow the mission of â€Å"one look, one voice†, meaning all Parker products would be sold and re-produced the same way in all countries the company would make partnership with overseas. As a result, all packaging and advertising would mirror the original Parker Pens in all participating countries. The problems which would arise from this is that standardization may not cater to different countries, who may have an interest for specific supply of pens. For example, locations such as France and Italy are fond of expensive fountain pens. Consequently, promotion strategies would lead to the decisions with regards to the distribution of products. Parker wanted all his pens to focus on a common positioning, which meant that the same types of pens would be allocated to its specified locations. The problem here is that the target markets values and interests are different across different markets, and cannot be dealt with similarly. Parker failed to realize that that you cannot use the same tactics on all individuals because each individual is unique in their own way. On the same note, this reduces the level of customization and personal preference. This also reduces customer consideration and individuals do not feel there is a sense of providing customer satisfaction. For the product, Parker pens lose its value in the pen industry for providing individuals with the writing instruments they need and have a value in. The Janesville strategy was a failure also due to the fact of pricing barriers. As stated in the article, Parker produced low-cost pens, which were not functional and were unable to do what they were intended to do. Leading up to this was a large controversy on the goodwill of the company in comparison to their actual products. Parker pen was a known as a company of quality, yet with this new global strategy, they failed to reduce costs yet at the same time satisfy the needs of customers. 2. -What role do people play in implementing any strategic decision? Analyze the role of Mr. Peterson, Mr. Smith and Mr. Parker. During the crisis of Parker pen, there were many roles being played. Mr. Peterson worked at reducing costs by laying off employees to reducing the product line to 100. He believed that entering into the global industry, it would require a single â€Å"world class agency†. Both Mr. Peterson and Mr. Smith decided that Parker pens needed to target the low-end of the market, meaning low cost pens would need to be produced. This would also result in the pens being in lower quality and standards than the original Parker pens. Mr. Smith, being promoted as the new president of the Parker pen company, planned to develop the Vector on the high scale and a disposable pen named the Itala on the low scale. Mr. Smith wanted Parker pens to take on markets of the pen industry that has never been done by any other company before. He decided that this would be the success of the company in entering into the global markets. For the company, this was a large risk as green ventures are unknown are this may cause a large fall in profits and sales. Mr. Smith also researched on the sales of Parker pens and discovered that the company had only a small share in the pen industry as most of its profits were coming from pens selling for less than three dollars. Mr. Smith decided that a change was needed, therefore pushed for the promotion of high scale to low scale products. Under the management of Mr. Peterson and Mr. Smith, 400 company managers were trained to market Parker products the same way in all locations. On the other hand, Mr. Parker was a believer of new product development, turning Parker pens into a company producing over 500 lines of products. His thoughts on the development of the global market were contrary to the ideas of Mr. Peterson and Mr. Smith. 3. -Was it a good idea for Parker Pen to produce and sell a wide range of pens from high-cost to low-cost? Why? It was not a good alternative for Parker Pen to produce and sell pens ranging from high-cost to low-cost. Parker pens are known for the quality in writing instruments and changing their production process by purchasing reduced quality materials will diminish the goodwill of the company. The first decision of determining if a company should globalize consist of the following items: knowing the company and its strength and weaknesses, knowing the product and its selling points, knowing the home market, knowing the target market and its background, and being able to leaves one’s predetermined values, beliefs, and propositions. There are many factors that need to be taken into consideration. Contrarily, the concept of having a wide range of products can be a success if adequate research was done to understand each markets’ values. In low growth developing countries, the most viable option may be to sell low cost pens because individuals may not have the ability to afford prestigious ones. 4. -If customers from different places are buying similar products, do you think it is possible to approach different markets with the same advertising theme? Why? Customers from different places may have values in buying similar products, but it is not possible to approach different markets with the same advertising theme. The reason for this is that you need to custom to each market. You need to change your advertising strategies according to the values of that particular location. For example, some locations may want to feel a personal message directed towards them in order to attract them while others may want advertising to be assertive and straightforward without any underlying messages. By assisting distribution to extensive research, Parker Pens can gain a larger understanding of each markets’ needs when dealing with promotional planning and marketing strategies. In other words, Parker Pen took on the concept of Ethnocentrism and Geocentrism, which means that the use of strategies are the same for all countries worldwide as it is in the home country. This may be both beneficial and detrimental for a company’s marketing process. Looking at standardization versus adaptation, a potential starting point for Parker Pen could be standardization; however, a company must also know when to make a change. Subsequently, adaption and modification of products would need to be implemented in order to maintain brand recognition in a global society. 5. -Which had been your recommendation for the international marketing plan of Parker Pen in 1982? Since Parker pens was previously established as an industry of high quality writing instruments. With a product line of 500, the company should have done more research and evaluation of each international target market before pushing their products into that particular country. Since Parker Pen is a company of no direct foreign marketing, in determining which products should be distributed can be handed to an expert and advisor who will perform that research. Market selection is done using secondary data from previous companies who may have been successful in international markets. Another option is to use precedence to determine whether the company will survive in the global industry. In the Strategic Decisions in International Expansion model, Parker Pen did not go through the decisions of determining whether the company was export ready and what modes of entry the company would enter by. There was a lack of strategy implemented on the marketing mix and how the company were to distribute their resources. For Parker Pen, there was an overuse of self-reference criterion, where both Mr. Peterson and Mr. Smith believed that a high volume of low-costing pens would perform well in locations overseas. This was a failure to realize differences and be able to put down one’s own values and accept the values of customers and the target market. Consequently, there was a lack of evaluation and knowing thy target. Segmentation variables are those that involve the demographics of each individual. In high developing countries, there may be a larger group of young individuals who are looking for affordable working pens to get them through the day at school, while in high business and technology based environments, individuals may value higher-priced pens because it produces an image of respect and status.

Friday, August 30, 2019

Philippines: The National Achievement Test Essay

To assess and monitor the quality of basic education in the Philippines, achievement tests were administered to public schools both elementary and secondary. These achievement tests include National Achievement Test (NAT), Regional Achievement Test (RAT) and Division Achievement Test (DAT). Of these three achievements tests, the NAT is the main criterion of the school performance. Meanwhile, the RAT and DAT served as preparatory assessment procedures to be able the school to determine its readiness for the |NAT. The National Achievement Test (NAT) is a Philippine-made standardized test designed to determine pupils/students’ achievement level, strengths and weaknesses in five key curricular subject areas at the end of the school year. The NAT was developed to measure what pupils/students in grade three, grade six and fourth Year know and can do in five subject areas: Science, Mathematics, English, Filipino, and HeKaSi (Heograpiya, Kasaysayan at Sibika) in elementary and Araling Panlipunan in secondary level. Specifically, the test aims to: 1.) provide empirical information on the achievement level of pupils/students, to serve as guide for policy makers, administrators, curriculum planners , supervisors, principals and teachers in their respective courses of action 2.) identify and analyze variations on achievement levels across the years by region, division, school and other variables and 3.) determine the rate of improvement in basic education with respect to individual schools within certain time frames. Target clienteles of this achievement test are Grade 3 students of public schools, Grade 6 students both public and private schools (census) and Year 4 students both in public and private schools (census). It is composed of 310 items divided into learning areas such as Science, Mathematics, English, Filipino, Araling Panlipunan, plus critical thinking.

Thursday, August 29, 2019

Building an Ethical Organization Essay

When building an organization the main focus will be to help the public with specific needs. We will have to build the business on ethics and human service laws. The main goal is to help those in need and do this with respect and caring. There are many ways to run an organization and we need to choose the right services to meet the needs in the community we serve. The organization is for the help for people living with Alzheimer’s and the people that love them. We will be there to offer services for the person suffering from the disease and their families. The services offered will be assistance at home, a live in if necessary, counseling for the family, and client, and a residential home. Services include shopping, sitting when a day out might be needed. We will offer a class to help the family understand the disease and its progression, and have group counseling to help them support each other. This is a not for profit organization. Helping people should be top priority over making money. Human services are about helping the people in our communities in need of services. The mission statement: To support and develop programs through education to teach how to live with the daily changes, and to strengthen family ties. We have to let them know they can count on us for understanding and support. This will support the ethical system by keeping the respect and dignity of our clients, supporting them in their time of need, and giving the family the support that is needed to face the day-to-day heartache that comes with watching your loved one suffer. The message that this mission statement will put out in the community is we will be there for them. We will not turn them away when the need is there. We have let the community know they can count on us to provide the necessary services to their loved ones, and also help them through a difficult time. Coping with this disease is not an easy thing to do. The services that will be provided will help the families understand  that this does not have to be a burden, and will help them to know that their loved one is getting the necessary care and love to help them in the progression of this disease. Having an ethical leader in the organization will help to have ethical social workers. Having a leader that is respected and trusted in the community will benefit the organization as well as the community and clients. The organization is only as good as its leaders. Our values in the organization will be: Commitment to the public, commitment to superior service and to maintain the publicâ₠¬â„¢s trust, and respect. Having empathy for our clients and their families, dignity and self-worth of all that seek help, and the importance of human relationships. Respecting the diversity of our clients and their families at all times, and we will not discriminate against anyone for any reason. Treating our clients with the dignity and respect that every human being is entitled to is what can be expected when they walk through the door. This helps support the vision that the organization has for its future. To have our clients and their families living with dignity and having control over a terrible disease, to have the community see and know that our clients receive the services to have as happy a life as possible. The staff will be highly trained in the area of Alzheimer’s to assist, and care for our clients, and be there to help the families with all the means available to the organization. We can put all this into action within the organization, and this will benefit the clients and community as well as the employees. We need an ethical leader who can set an example for the employees. The leader will need to always show their leadership with the ethics that we want to have within the organization. This will help teach the employees how to behave and always keep the mission in mind and work toward the vision that the organization has for the community and the clients. Abiding by the ethics laws and the hum an service laws will help with the code of conduct that is expected of all employees in the organization. According to Statement of values and code of ethics for nonprofit and philanthropic organizations (2004) â€Å"going through the process with the board and staff also begins to infuse into the culture of the organization recognition of how important it is to address issues of values and ethics on an ongoing basis†. All the employees need to be involved with the process so they fully understand what is expected of their behavior in the organization every day. When difficult situations arise with clients all  employees will handle the situation the same way, and make sure that the client has their needs met in an ethical and respectful way. Social workers have a code of ethics that are an important part of the job. According to NASW (2013) â€Å"social workers have an ethical responsibility to their clients, self-determination, competence, social diversity, privacy and confidentiality†. All laws will be posted around the organization so they will be seen daily and keep the mission in the minds of the employees daily. Our clients will respect the organization and the employees for always using ethical conduct and fairness when it concerns helping them find the right services that work. If more services are needed than we have to offer the clients they can have peace knowing they will be sent to an ethical place to have the services needed that will work together with what we offer the clients. When a social worker in the organizati on as not conducted themselves in an ethical way, and has caused problems will be reprimanded. The client’s dignity comes first in the organization. Dealing with a disease that has no cure is devastating to the family, and it is a horrific disease for the client to deal with. Having caring people treating them with love and respect makes a big difference in their world. Offering as much assistance as we can by the programs we have and services we offer will make a big difference in their day-to-day routine. Letting them know they are not alone, and we will be there to make it a bit easier to get through. References: Statement of values and code of ethics for nonprofit and philanthropic organizations. (2004). Retrieved from http://www.ncdsv.org/images/ NASW. (2013). Retrieved from http://www.socialworkers.org/pubs/cod

Wednesday, August 28, 2019

Managing the Digital Enterprise Essay Example | Topics and Well Written Essays - 2000 words

Managing the Digital Enterprise - Essay Example From this definition, information system is an arrangement of data, technology, processes, and groups that function together to collect, provide, store, and process information output required to improve and increase the speed of the decision making process. In the past decade, various organizations have began utilizing computer technology to facilitate the provision of services and the process of adoption is expected to increase at a higher rate as technology advances (Hamdan and Jalal-Karim 2010, p1). This paper focuses on the impact of modern digital technologies on the banking sector with a bias toward electronic banking. 1.2 Banking Activities and Developments in IT All aspects of the banking activity are influenced and continue to be influenced by the development of information transmission, distribution, processing, storage, and collection. Developments in information technology affect the banking industry in two ways. Firstly, the information technology contributes in the dec rease of the costs linked with information management (information is managed by means such as processing, transmission, collection, and storage) through the replacement of labour-intensive and paper-based methods with processes that are automated. Secondly and lastly, information technology modifies the ways through which the consumers access the bank’s products and services, for instance, through automated channels such as remote banking. Developments in information management have been occurring for a considerable length of time but remote banking (the latest phenomenon in the banking industry) developments are occurring more gradually especially within retail banking (European Central Bank 1999, p5). Business model can be utilized to describe the main components of any banking business. In regard to the differentiation of the bricks-and-mortar banking from e-banking, there are five crucial dimensions of the business model and they include market scope, profit potential, v alue network, cost structure, and value proposition. Since consumers are capable of electronic banking over the internet regardless of the time and location, electronic banking eradicates time limitations, and physical and geographic boundaries linked with bricks-and-mortar banking. Electronic banking also offers consumers with efficient online financial services (the services are offered at high speed and they are time saving). Additionally, through the internet, the consumers are able to access numerous information and services (Heng, Hsia, and Wu 2006, p115). 1.2.1 Electronic banking and its value The convenience resulting from electronic banking has three considerable impacts. Firstly, it may lead to information symmetry where the consumers can access more information than through the bank; the consumers may opt to avoid the bank for services provided through alternative parties (SCN Education

Tuesday, August 27, 2019

Pakistan's international conflict between secularism and Islamic Essay

Pakistan's international conflict between secularism and Islamic militancy - Essay Example However, the Indian population had its own cultural characteristics with the original Hindu majority interspersed with a large population of Muslims, a remnant of the country’s bygone Mughal era. The Muslim population feared dominance in a vastly Hindu populated region and this fear prompted its leaders to suggest a separate state for the Muslims. The British rulers, who had handled such issues in their two centuries old reign in the region, recognized this factionalism in Indian society and with the perception that the demand was reasonable, acceded to the creation of a separate country for the Muslims. With the Muslim higher intensity of Muslim population in the Northern region of Punjab and the Eastern state of Bengal, it was decided that East and West Pakistan were two entities that would suit the purpose. Accordingly, the Sub-Continent was carved into two states, the independent republic of India and Pakistan, the latter with its two landmasses separated from each other. West Pakistan lay in the north west of the subcontinent with majority population being Punjabis, and East Pakistan at the extreme east of the subcontinent, the majority population being Bengalis. ... The remaining Pakistan in the West was the only surviving Muslim dominated region in the Indian sub-continent which has been driven by hatred for its neighbours, India and Afghanistan, rather than being an independent, progressive state as was envisaged by its creators. The country has been through numerous coups, alternating with short periods of a semblance of democracy, the latter being throttled ruthlessly by military rulers through assassinations, murder and mayhem. The Cold War era saw attempts of domination in the region by the then two superpowers, the United States and the former USSR (Union of Soviet Socialist Republics). Afghanistan had its own internal problems and remained occupied by Soviet forces for almost ten years during the Cold War. This prompted the United States to pump in economic and arms aid to Pakistan, which gleefully accepted the alms to fuel its hatred and threat to India. Although claiming to be a Muslim country, the Pakistani rulers did not hesitate to ally with China, an atheist state, taking advantage of its border dispute with India. The United States assisted Pakistan to form the Taliban, a radical Muslim organization, with an aim to cripple the USSR presence in Afghanistan, which it did with some degree of success. However, after designs of the west and internal economic and political unrest forced the dismantling of USSR, it lost interest in Afghanistan. The Taliban was left without any purpose, or the need for its existence as an entity. But the large number of youth who were recruited into the organization rebelled and trained their guns on the very creators of their organization, the United States of America. Muslim radical organizations like the now famous Al Qaida grew from West Asia and expanded into the Muslim

Monday, August 26, 2019

Criminal Justice Essay Example | Topics and Well Written Essays - 1000 words - 1

Criminal Justice - Essay Example As a result, the needs of the female prisoners are often disregarded thus negatively affecting their mental and physical health in the process. It has also been observed that the failure to meet the needs of the female prisoners deprives them of their right to basic dignity and leads to the violation of their fundamental human rights (Law and Whitehorn, 2012). Some of the key issues commonly faced by female prisoners include custodial sexual misconduct; caring for their children; lack of availability of adequate healthcare facilities suited for their needs; lack of accessible services; vulnerability to abuse; etc among others. The needs and concerns of female prisoners are starkly different as compared to their male counterparts, a fact which has been largely ignored so far. Unlike men, the female prisoners are solely responsible for caring for their young children. In such a situation, isolation due to confinement inevitably takes a toll on their mental health. Furthermore they are relatively more vulnerable to abuse and neglect in prison due to the differences in the sexual and reproductive health as compared to males. Issues such as these are hence likely to aggravate the mental and health problems faced by them (UN Office of Drugs and Crime, 2008). Women are also found to be highly vulnerable to prison abuse (Clear, Reisig, and Cole, 2012). Their mental health in particular is far more likely to deteriorate while in confinement due to factors such as overcrowding, lack of proper assessment procedures, discomfort on account of being supervised by male staff, etc (McElreath, Keena, Elter and Stuart, 2011; Stohr, Hemmens, and Walsh, 2008). Furthermore it has also been observed by various researchers that women are more prone to attempt suicide while in confinement due to mental stress and trauma, and lack of availability of appropriate healthcare facilities to address their specific healthcare needs (Petersilia and Reitz, 2012). Critical evaluation: There has been a significant rise in the number of female prisoners in the United States during the past two decades. This sudden increase of female offenders can largely be contributed to stricter punishment and longer incarceration for drug offenders, as a part of the war on drugs campaign. Thus, the policies introduced by the administration to eliminate and / or reduce the disparities in sentencing, ultimately led to the rise of female inmates behind bars (Stange, Oyster, and Sloan, 2011; Miller, 2009). According to the American Civil Liberties Union, women comprise of the fastest growing segment of the incarcerated population, increasing at nearly double the rate of men, in the United States (ACLU, 2007). There is substantial evidence indicating the substantial over-representation of women of color in the American prisons as well as the criminal justice system, with Blacks and Hispanics comprising of the largest female population behind bars (Law and Whitehorn, 2012; Oberman and Meyer, 20 08). Some of the key reasons behind the increased incarceration rates of females belonging to the minority population include poverty, and unemployment which significantly hampers their ability to provide and care for their families. Their demographic and socio-economic background makes them highly prone to commit economically driven crimes such as property crimes, prostitution and at times drug

Leadin organizational design Essay Example | Topics and Well Written Essays - 500 words

Leadin organizational design - Essay Example There is no single right approach. From the experience we got from the exercise, it is clear that solid arranging practice is basic to change administration victory. There are numerous change situations that call for some diverse reactions. Maybe expanding rivalry requests another concentrate on holding existing clients? Then again perhaps extraordinary business victory is bringing about developing aches? It is safe to say that you are ceaselessly filtering the natures turf (markets and rivalry)? Be vigilant in administering attention to the outer environment so the need for change could be promptly recognized. Additionally, it is important to note that a participative arranging procedure is basic to change administration victory. Despite the fact that change may be started by a singular, key stakeholders should additionally thoroughly consider and comprehend need for change. Furthermore, stakeholders must experience the improvement of vision and method. A thorough and normally prolonged methodology of data imparting and dialog is important to make arrangement of the center gathering. Time and vitality went through in intense gatherings with the right individuals will transform stronger systems and solid authority all around the association. On the off chance that these tests are succeed, the change activity will profit from a solid vision and system upheld by a solid, profoundly adj usted center change management as it is the case with Global Tech. William Bridges work is concentrated on the mental process that people experience when adjusting to change. Associations that utilize the Transitions model highlight the exact individual and in some cases excruciating excursion that happens when we relinquish the past and end up in the unbiased zone, on our route to a fresh start. Once more, EC tests pioneers to think about scaling the singular brain science

Sunday, August 25, 2019

The Alibaba Group Holding Limited and the Aspect of Disruption Essay

The Alibaba Group Holding Limited and the Aspect of Disruption - Essay Example Notable is that innovation within human societies is as old as history itself. However, it is only from the 19th Century onwards that the greatest level of human advancement vis-à  -vis the period has taken has exceedingly amplified. This has, in turn, influenced the manner in which enterprises conduct their business, especially in the face of increased global competition. As a Chinese e-commerce firm-entity, the Alibaba Group Holding Limited provides platforms on which online sales services can be safely conducted, via available web portals. Most importantly is the crucial element of continuous technological advancement (Schepp & Schepp, 2010). This has availed a platform on which business can be effectively and efficiently conducted online, with some form of security assurance. With enhanced cybersecurity measures, and a growth in consumer confidence in e-commerce has availed a robust and lucrative market arena that remains significantly untapped (Nonaka & Zhu, 2012). As an entity concerned primarily with the provision of sales services, i.e. business-to-business, consumer-to-business or consumer-to-consumer basis, the Alibaba Group is also a provider of other services. These include data-centric cloud computing services, a very successful shopping search engine and electronic payment services. It is important to note that the entity is sector-specific, with its business strategy focusing on technology-supported and enhanced service provision. Taobao, Alibaba’s consumer-to-consumer internet portal is similar to America’s eBay.com. Due to the large-scale nature of the Chinese market arena, the entity features almost a billion products and brands, targeting the multi-billion consumer market. Globally, the website is amongst the 20 most-visited, accounting for over 60% of all parcels delivered in the PRC (Gifford, 2013). This in itself attests to the rapid uptake it has  experienced in this market, further influencing future strategies of market venturing and expansion.  

Saturday, August 24, 2019

Advantages and Disadvantages of a PRP System Research Paper

Advantages and Disadvantages of a PRP System - Research Paper Example PRP system was a big idea of the late 1980s. It was viewed as the answer for motivating people and developing their performance. Nearly 40% of the organizations used in 1998 for management, 25% for non-management. The wave turned reverse PRP in the 1990s when the previous schemes were not delivering the expected results. Extensive innovations in compensation systems and, in particular, a variety of attempts to link pay to a measure of performance have been witnessed in recent years. Those innovations have been related to wider initiatives in order to improve the performance of organisations and in particular efforts to increase employee involvement. On the whole, there has been systematic research on the effects of performance-related pay (PRP) schemes. Also, existing results seems a little bit contradictory, with some studies suggesting that PRP schemes might have a positive influence on organisational performance. The majority of existing research focuses on individual-based PRP, e specially piece-rates, in spite of the existence of a wide variety of schemes that are neither based on individual performance nor even a tangible measure of output. Many PRP schemes focus on paying to a work-group or firm performance measures. Some, on the other hand, is based on subjective measures of output, such as merit pay. There are also schemes that link a component of pay to the profits of the organisation or offer employee’s shares in lieu of cash as forms of team PRP scheme. Furthermore, these can also be regarded as similar to PRP schemes, although involving a very indirect link between performance and pay.

Friday, August 23, 2019

What defines developmental apraxia of speech How and why does it Essay - 1

What defines developmental apraxia of speech How and why does it differ from acquired apraxia of speech - Essay Example Given the nature of this disorder, it is difficult to define it. Guyette and Diedrich doubt it is possible to define DAS in the normal sense as â€Å"there is little reported agreement on which symptoms the behaviors are important in the diagnosis of this disorder. Second, there is paucity of data to support claims even when agreement is found† (as cited in Bishop & Rosenbloom, 1987, p. 30). This view notwithstanding, various definitions have been propounded for DAS. Hegde (2001) states that it is a â€Å"disorder in children characterized by sensorimotor problems in positioning and sequentially moving muscles for the volitional production of speech, associated with prosodic problems† (p. 184). Caruso and Strand (1999), state that most definitions of developmental apraxia of speech â€Å"focus on the inability or difficulty with the ability to perform purposeful voluntary movements for speech, in the absence of paralysis or weakness of the speech musculature† (p. 14). Despite lack of evidence and consensus regarding the symptoms and characteristic features of DAS, certain diagnostic symptoms have generally been agreed upon. â€Å"These comprise a high number of consonant errors, especially substitution in place of articulation, inconsistency in repeated productions, difficulty in sequencing phonemes, especially in diadochokinetic tasks (/pataka/), groping, and resistance to therapy† (Nijland & Maassen, 2005, p. 138). Other diagnostic criteria include errors in articulation, use of vowels, lack of comprehensive skills, faulty sequencing and rhythm of speech. However it cannot be said with any degree of certainty that these symptoms are exclusive to DAS. Shriberg, Aram and Kwiatkowski (1997b) attempted to find one diagnostic marker that was exclusive to DAS and that served to differentiate it from children with delayed speech and found â€Å"inappropriate stress the only characteristic significantly differentiating the two

Thursday, August 22, 2019

Direct Seeding Literature Review Essay Example for Free

Direct Seeding Literature Review Essay Introduction: The world’s total forest area is just over 4 billion hectares, which corresponds to an average of 0.6 ha per capita (Figure 1). The five most forest-rich countries (the Russian Federation, Brazil, Canada, the United States of America and China) account for more than half of the total forest area. Deforestation – mainly the conversion of tropical forest to agricultural land – shows signs of decreasing in several countries. Around 13 million hectares of forest were converted to other uses or lost through natural causes each year in the last decade. At a regional level, South America suffered the largest net loss of forests between 2000 and 2010 – about 4.0 million hectares per year – followed by Africa, which lost3.4 million hectares annually (Figure 5). Oceania also reported a net loss of forest (about 700 000 ha per year over the period 2000–2010), mainly due to large losses of forests in Australia, where severe drought and forest fires have exacerbated the loss of forest since 2000. Asia, which had a net loss of forest of some 600 000 ha annually in the 1990s. Need of Forest Restoration: Within the last ten years, tropical rainforests have been destroyed at an annual rate of 0.8% of area (Whitemore, 1997). So this things brings to human being to think about the forest restoration. Forest restoration is defined as â€Å"actions to re-instate ecological processes, which accelerate recovery of forest structure, ecological functioning and biodiversity levels towards those typical of climax forest† Various forest restoration methods have been developed, for instance, the accelerated natural regeneration ( ANR) (Jansen and Pfeifer , 1989), The Framework Species method(Goosem Tucker, 1995) and The Maximum Species Diversity method. The ANR method is Effective where natural regeneration is already underway. Eliminates nursery and tree planting costs. Relatively cheap – Capitalizes on â€Å"free† ecological services US$ 1,400/ha. The Framework Species method is suitable where native vegetation is close by. Its only need a single planting and it is self sustaining. In the Maximum Species Diversity method a large percentage of species are from the mature phase and primary promoters are avoided. The major disadvantage of this method slower growth rate and post planting management is required. Now a days there is some evidence that , reforestation plays a key role in the long term of restoration of landscape functioning, as well as social and economic development. Reforestation can catalyses and induce succession of forest ecosystems using native species (Parrotta, 2000). Direct Seeding: An ancient method of establishing trees is by sowing seeds directly where the future trees are required. In many circumstances, this method is superior to the traditional method of planting nursery-raised plants. In several tropical countries, the demand for reforestation is often not met due to limited resources. Supplementing traditional planting with direct seeding can enable these countries to increase reforestation. Direct seeding is a regeneration method of sowing seeds directly where the future trees are required, whether it is for forest plantations, shelterbelts or in agroforestry. In this way the laborious task of raising nursery plants and transplanting them to the planting site is omitted. Direct seeding offers various interesting possibilities e.g. the ability to rapidly increase the area being forested or the ability to provide rural people with an inexpensive method to obtain benefits from trees. History of Direct Seeding: Direct seeding has over the last 50 years gained in importance, especially in North America and China where large areas have been direct seeded from helicopters or aero planes. Direct seeding from the air has been widely used in China where more than 15 million ha have been reforested between 1956 and 1985 (Xinhua Jingchun, 1988). In the developed countries more than 1⠁„2 million ha were reported to be direct seeded in 1974 or about 20 % of the area being planted (Appleroth, 1975). Direct seeding in the tropics is less reported compared with the subtropics (Australia and USA) or the temperate regions (USA, Canada and Scandinavia). Trials have been carried out and reported from various tropical countries for example Indonesia, Philippines, India, Central America, Northern Australia and the Sahel in Africa. Direct seeding in the tropics has been carried out many times without the results ever being published. In the dry tropics traditional forestry is limited and most trees are r aised in connection with agriculture. Here, direct seeding already plays an important role, this could increase in the future by being implemented in afforestation and in establishment of shelterbelts. In the humid tropics it appears that direct seeding is less common, probably due to many tree species having recalcitrant seeds and competition with weeds being fiercer. Nevertheless direct seeding has the ability to contribute significantly to tropical forestry in the future, probably not as the main regeneration method but as a method that under certain circumstances is superior to other methods. The following will describe various scenarios where direct seeding is employed in the tropics. Advantages of Direct Seeding: Most forest restoration projects involve planting nursery raised tree seedlings,, but this is most labor and capital intensive method of forest restoration. Seed collection, raising seedlings in a nursery, planting and maintaining planted saplings until they can establish and become independent all require substantial labor inputs (Hardwick et al., 2000). Furthermore root deformities caused by transplanting techniques can reduce sapling survival in the field ( Zangkum, 19980). The Potential advantages of direct seeding over other plantation establishment techniques include cost savings associated with nursery care and planting as well as the possibility that trees established by this means may develop more naturally or quickly, than would transplanted seedlings or cuttings( Engel Parrotta,2001). The Eden Project in Niger is recommending direct seeding as an appropriate method of establishing trees where water is scarce (Eden Foundation, 2000). It is claimed that nursery plant use precious irrigation water, whereas direct seeding carried out prior to or during the rainy season does not need irrigation. They further maintain that plantation established by direct seeding tend to produce extensive root system, whereas the above ground shoots grow more slowly. In contrast seedlings in nurseries tend to produce large shoots and have to be irrigated or they they will suffer high mortality, whereas plants that established through direct seeding are more likely to be able to reach moisture remaining in the soil after rainy season.(Oschner,2001). This was quantified by Samba (1992) who sowed the seeds of Faidherbia albida at the same time as planting as planting nursery raised plants. Four months after sowing direct seeded plants were about twice as tall and had a mean dry root mass 25 times higher than that of the nursery raised plants. The disadvantages of Direct Seeding: The significant disadvantages of direct seeding that can outweigh these advantages include low germination survival percentages, seedling mortality associated with weed competition and also poor weather condition (Evans, 1982). Steven stated that the results of direct seeding are affected by a number of factors including species, soil conditions, site preparation and techniques for seed germination. Garwood (1989) pointed out that seed destructed by animals also plays a key role in reducing seed germination. Direct Seeding in different purposes: Direct deeding can used for many purposes like for plantation, restoration, in mine spoils rehabilitation, in agro forestry. Negreros et al., 2003 worked in Mexico to restore the area by Mahogany seeds. Because this is very valuable for timber. He found that Burying Mahogany seeds were clearly better than sowing them on the soil surface and it yields double comapared to sowing method. For restoration purposes by direct seeding method, Tunjai and Elliott (2011) found that seed trait is very important to achieve the goal of forest restoration by this method. They said Large or intermediate sized seeds, Round or oval seeds, Medium or low moisture content seeds showed good establishment when they sowed in the field for forest restoration purposes. For mine site rehabilitation Parrotta and Knowles(2001) found that In term of species richness, densities and life span over 40 years Direct seeding got the most priority. They experimented with four forest restoration techniques and direct seeding showed the good result for rehabilitation mine site in Brazil. Factors effecting seed germination when applied by direct seeding: Seed germination is the activation of the metabolic machinery of the embryo, leading to the emergence of a new seedling ( Poulsen and Stubsgaard, 1995). Seeds of some species do not germinate due to hard seeed coats hindering intake of water ( Baskin Baskin, 1998). Seed treatments can be applied to break dormancy and improve the seed coat permeability. For germination to be initiated three conditions must be fulfilled: first seeds must be viable that the embryo must be alive and capable of germination. Second, the seed must be subjected to a proper environmental conditions, available water, proper temperatures, a supply of oxygen and sometimes light. Third dormancy must be overcome. ( Poulsen and Stubsgaard, 1995).However seed treatments can be applied to break dormancy and impro ve seed coat permeability such as scarification, soaking in water or boiling in hot water or hot sand.( Hardwick Elliott,1992). Problems with weeds: Studies conducted by Sun, Dickson and Bragg ( 1995) in Australia, found that the survival and early growth of Alphitonia petriei through direct seeding are largely affected by weed competition and site conditions. The death of germinated seedlings, a few weeks after germination in the plots where weeds remained undisturbed through out the experiment, was mot likely due to the effects of competition for light from the existing weeds. Results from both the glasshouse and field experiments also indicate that weed compition severely limited the early growth of Alphitonia. Frequent weeding is necessary during the early growth phase.(Engel Parrotta 2001). Problems with predation: Seed predation can be severe and looses up to 100% have been reported. (Crawley, 1992). Seed predation has identified as one of the biotic barriers to natural forest regeneration in the abandoned Amazon pasture derived from rainforest ( Nepstad et al., 1991). Garwood (1989) pointed out that seed destructed by animals also play vital roles in reducing seed germination. However Crouch And Radwan (1975) recommending seed coating and pelleting against seed predators. But little is known about this technique in tropical situation. The study of Woods and Elliott (2004) was designed based on the premise that scarifying seeds before sowing them in the fields cleared of weeds would shorten seed dormancy to decrease the time available for seed predation to occur and that burial conceals seeds from potential predator. They found that ants were the only predator observed. Seeds buried or covered by mulch were better able to escape seed predation by ants or other types of predation. Other problems: The results from Sun et al., 1995 showed that compacted and eroded soils are inhospitable to the establishment of A. petriei seedlings. So,at this point site preparation is necessary to overcome this problem. Points to achieve succession of using direct seeding: Sun et al.1995 conclude that weed control and maintenance of nutrient levels are essential for success. Engel and Parrotta (2001) suggested that what is required is a more systematic screening of potential species and their response to direct seeding under field conditions and evaluation of coast associated with plantation establishment and aftercare. Seed quality is also other concern, using fresh seeds collected from several parent trees growing on sites where soil and climatic conditions are similar to those being reforested and planting should be carried on high rainfall. Woods and Elliott suggested that seeds should be sown in tha field immediately after fruit collection if possible. In order to minimize seed storage, species selected for dirct seeding should fruit at the beginning of the rainy season when direct seeding is most likely to be successful. Areas where direct Seeding could get an importence: Many tropical species have recalcitrant seeds, e.g. most trees in the dipterocarp family. This means that the seeds deteriorate rapidly after collection and can only be stored for a short period. If transport and temporary storage can be reduced to a minimum by processing the seedlot at the collection site before direct seeding the seeds at the planned site, the whole operation may be done in fewer days compared to a solution with a central processing centre and a nursery. This solution should result in a seedlot with better germination and possibly a higher overall percentage of established plants. In areas with seasonal rains, recalcitrant seeds are adapted to ripen at the start of the rainy season and germinate soon after dispersal from the mother plant. Time for direct seeding will thus naturally be at the beginning of the wet season, just after collection of the seeds, where the rains will provide a good start for the seedlings. In contrast, nursery stock has to be planted out a year after seed collection at the onset of the next rainy season or alternatively at a time where drought can hinder the growth and survival of the seedlings. Many species will reach a fair size after a year in the nursery, resulting in more costly transport and planting of nursery stock compared to direct seeding. In Southeast Asia large areas of former rain forest lands have been turned into imperata (Imperata cylindrica) grassland, due to failure of reforestation. In Indonesia alone the latest estimate of Imperata grasslands is 8,6 million ha (Garrity et al. 1997). In these areas it is difficult for trees to establish naturally due to annual fires. Direct seeding in connection with constructing fire-belts could perhaps offer an alternative method to reforest these areas. In a trial in Jamaica a variety of trees was successfully established on grassland (Roshetko et al. 1991, 1991). It was concluded that trees can be established by direct seeding even with heavy grass competition, providing that monthly weeding is carried out until trees reach a competitive size. In a Nigerian trial Gliricidia sepium was both planted and direct seeded in Panicum maximum pastures after mechanical seedbed preparation (Cobbina 1994). Although planting showed better results, direct seeding could still offer a worthwhile alternative if expenses are taken into account. In order to compete with the imperata grass it would be sensible to start the reforestation with fast growing exotic tree species for example Acacia spp., Leucaena, Cajanus cajan or Sesbania spp. In order to obtain more valuable forest products planting or direct seeding of native primary forest species such as dipterocarps could be carried out at a later stage when the grasses have been outcompeted. Otsamo (2000) reported that native trees can be establish in the understorey of fast growing plantation species; he found 63 tree species in plantations on Borneo, which was established on former Imperata grasslands. Costs and benefits: Angel and Parrotta (2001) reported that the establishment and maintenance cost of direct seeding of five species in Brazil during the 2 years study period averaged 747-912 US $ per hectare. This cost compare favorably with those for plantation establishment and maintenance at this site using nursery grown seedlings of native tree species in other plantation treatments include in same project , which averaged1200- 1500 US $.(Unpublished data).Therefore direct seeding in this project can reduce about 63% compared with the plantation using nursery grown seedlings. References: Appelroth, S.E. (1975). Work study aspects of planting and direct seeding in forestry. In Symposium Stand Establishment; Proceedings, p. 202-269. Engel, V. L. and J. Parrotta, 2001. An evaluation of direct seeding for reforestation of degraded lands in central Sao Paulo state, Brazil. Forest Ecology an Management 152:169-181. Garwood, N.C.1989. Tropical soil seed banks. In: M.A. Leck, V.T. Parker and R.L. Simpson (Eds.). Ecology of soil seed banks. Academic press Newyork, 149-210. Goosem, S. and N.I.I. Tucker.1995. Repairing the rainforest. Theory and practice of rainforest re establishment. Wet tropics management authority. Cairns, Queensland, Australia.72 pp. Hardwick K (1999) Tree colonization of abandoned agricultural clearings in seasonal tropical montane forest in nothern Thailand. In, vol. Doctor of Philosophy. University of Wales, Bangor,p 168. Jansen, C.L. and S. Pfeifer.1989. Assisted natural regeneration: a new reforestation approach. USAID report prepared for the development of environment and natural resources. Government of the Philippines 22pp. Negreros CP, Hall RB (1996) First-year results of partial overstory removal and direct seeding of mahogany (Swietenia macrophylla) in Quintana Roo, Mexico. Journal of Sustainable Forestry 3:65-76 Negreros, C. P. and R. B. Hall, 1996. First-year results of partial overstory removal and direct seeding of mahogany (Swietenia macrophylla) in Quintana Roo, Mexico. Journal of Sustainable Forestry 3:65-76 Oschner, P. 2001. Direct seeding in the tropics. IUFRO Joint symposium on tree seed technology. Physiology and tropical Silviculture, College of forestry Natural Resources, University of the Philippines, Los banos. Parrotta JA, Knowles OH (2001) Restoring tropical forests on lands mined for bauxite: Examples from the Brazilian Amazon. Ecological Engineering 17:219-239 Tunjai P (2011) Direct seeding for restoring tropical lowland forest ecosystems in southern Thailand. In, vol. Doctor of Philosophy. Walailak University, Nakhon Si Thammarat, p 192 Woods K, Elliott S (2004) Direct seeding fo r forest restoration on abandoned agricultural land in northern Thailand. Whitmore, T. C. 1997. Tropical rainforest disturbance disapperance and species loss.In: W.F. Laurance And R.O. bierregaard Jr. (eds.0 . Tropical forest remmnants:Ecology management and Conservation of fragmant communities.(pp.3-12). Journal of Tropical Forest Science 16:248-259. Xinhua, C. and Z. Jingchun. 1988. Sowing from the air: China’s experience. Tigerpaper vol. XV: No. 1. FAO forest news. http://www.fao.org/docrep/013/i1757e/i1757e.pdf Zangkum, S. 1998. Growing tree seedlings to restore forests: effects of container type and media on seedling growth and morphology. MSc thesis, Chiang Mai Univerity, Chiang Mai.

Wednesday, August 21, 2019

Social Normalities and Voicing of Opposition Essay Example for Free

Social Normalities and Voicing of Opposition Essay Brian Crane Throughout history, social norms have dictated the opinions of all members of society to a certain extent. Expressing disapproval of these social norms is a difficult and ambitious task, seeing as one challenging a social norm is essentially disputing, in addition to often disproving, the reasoning and opinions of the majority of any given culture. Take, for example, the ending of ones own life under the circumstances of terminal illness. Now, our basic and most common cultural view on the subject is that suicide is not a natural death and therefore a violation of nature regardless of nes physical condition. However, it is nature itself that has given us as humans the intellect to contemplate such a decision. If nature has enabled us to develop the intellectual ability to contemplate suicide, then one could argue that choosing to end ones life is in fact a natural death simply because nature has allowed us to examine the pros and cons of life or death. However, this is not to say that suicide based on emotional imbalance is in any way Just or morally acceptable. Mental illnesses, which often bring about suicidal deation, can be treated, therefore ridding one of all motivation to end their own life. Generally, those who suffer from mental illnesses cannot be held accountable for their own life because the affective disorder inhibits them from perceiving reality the way they once did. So, the argument that the time of our death should not be a decision we as humans can morally make is somewhat valid although very misguided. It is wrong to look down upon terminally ill people who choose suicide as their cause of death. The many different circumstances leading up to ones death akes this topic too complex for one to claim that choosing life over death is morally applicable and correct in every situation that involves the contemplation of suicide. John West discusses his fathers decision to end his life before enduring the pain, suffering, and eventual death caused by cancer in an excerpt from The Last Goodnights: Assisting My Parents with Their Suicides. Judging from this excerpt, West and his father seem to be very well rounded, cultured individuals in addition to being extremely open minded and emotionally balanced. Wests father was a very mportant fgure in the world of psychiatry. His knowledge on the topic of suicide is obviously very extensive. Their opinions and examinations of this topic are indeed equally as rational as they themselves are as people. Dealing with the death of a parent is hard enough emotionally as it is, but the fact that West is grounded enough to grapple with the complexity and sorrow of assisted suicide is a testament to his extreme emotional maturity. He sheds light on a crucial point in support of his fathers decision as he asks the reader, Should Jolly [my father] have been forced to endure a few more days or eeks of agony Just to satisfy some peoples notions that death should be natural? (33 West) If one were to explore the possible answers to the question West asks above, without an impartial view based on societal influences, it is undeniable that one would agree with the opinion that such a great deal of suffering is not necessary to tultill the requirements ot a morally sound death In tact, it is arguable that Wests decision to assist his father with his suicide and in-turn spare him from such a great deal of pain is actually a more compassionate choice in comparison to xposing him to months of unimaginable pain by denying his fathers request. Again, West implies that suicide is not a natural death. A supplemental argument to his case is missing. If one were to argue that suicide and natural death cannot possibly go hand in hand, then why has nature allowed our intellect to excel to a point at which suicide is even a possible conception for the human race? Later on in the excerpt, West reflects on his memory of when his father asked him to commit assisted suicide. He recalls: I sat up in my chair. I suddenly felt hot and cold at the same time, as I realized hat he meant. But as powerfully as his words registered, the idea behind them didnt seem strange at all. It made sense. He was about to die anyway, so why linger in pain? I knew Id want to do the same thing if I were in his position. (34 West) Jollys contemplation of suicide is undoubtedly a common one of people with analogous situations to his own. Most would find it hard to believe that this wouldnt cross the mind of a person with a terminal illness that would soon lead to unimaginable pain and suffering, followed by death. If exploration of suicide is in act a common happening, why is it that the practice of suicide to avoid agony followed by death is not more common as well? It seems as though the answer to this question is quite simple; It is socially unacceptable to commit such an act solely because it is abnormal. Because abnormality is not a sensible or rational reason not to do something, making the argument that suicide is not a morally righteous death is in-turn irrational and insensible as well. Another challenger of social norms is Catherine Newman, author of I Do. Not. : Why I Wont Marry. Although Newman discusses a very different topic than West does in his short story, the two subjects are very closely related. Newman is a successful writer with a little too much insight on the role of women in society, and the flaws of this role, to happily accept monogamy and more importantly marriage. She breaks down the history of marriage and its original role in society. Marriage represents a very evil concept that very few are even aware of. Newman describes it is as such: marriage is about handing the woman off, like a baton, from her father to her husband. Also known as traffic in women, this is how men have historically solidified their economic connections to other men and guaranteed the continuation of their Seed. (Newman 61) Women were more like bargaining chips for men than soulmates. Marriage is the legal bonding of two families, which doesnt sound very romantic as marriage is made out to be. Although women are no longer owned by their husbands, this ritual is still quite demeaning. Many women experience some feelings of inferiority and in-turn feelings of resentment towards men due to the heavy influence of the media and its bjectification of women. Newman seems to be a prime example of this. Her additional education on the history of the subject has given her an even greater grasp of the hardships of women in our contemporary society which are overlooked more often than not by the general population. Voicing out against the social norm of marriage is extremely commendable and in addition, a betterment of the mentality ot those who are exposed to the underlying implications ot such an act through ner courageous writing. It seems as though many social norms have become so routine to follow and abide y that we rarely ponder the ideas behind them.

Tuesday, August 20, 2019

T Cell Receptor and the B Cell Receptor: Comparison

T Cell Receptor and the B Cell Receptor: Comparison The entire world is full of pathogens which we need to fight off to leave a normal life. Due to this, we have an immune system that helps us fight off and prevent/manage subsequent infections. Our immune system can be classified into two, the innate and acquired immune responses. The innate immune response is broadly specific and provides the first defensive action against any infection. Their response to any subsequent infection stays the same as the initial infection. In contrast, the acquired immune response is highly specific such that it provides defence by generating antibodies specific to an antigen. They also have the capacity of keeping infection memory such that there will be a more powerful response to future infections. Innate immune response is mostly provided by macrophages, dendritic cells, polymorphonuclear leukocytes, mast cells, natural killer cells, erythrocytes and platelets. The acquired immune response is provided by lymphocytes, the T (T cells) and B lymphocyte s (B cells). The lymphocytes are derived from hematopoietic stem cells (HSC) in the bone marrow. That form MLPs (myeloid-lymphoid progenitors). If the HSC and MLP stay in the bone marrow they form B cells and if they migrate (via blood) to the thymus they form T cells (see figure below). Initiation of immune response by the lymphocytes first requires recognition of the antigens and this is achieved by cell surface receptors called BCRs (B cell receptor) and TCRs (T cell receptor). These two receptors have great similarities and differences in their structure complexes, antigen recognition, cell activation and genetic recombination. A) STRUCTURE OF BCRs AND TCRs Both the BCR and TCR have great similarities and differences in the structure. They both exist as multi-chain complexes as seen in the diagrams below: i) Antigen recognition components In the figure above, section A shows the structure of a BCR. The BCR antigen recognition medium is an immunoglobulin (Ig) molecule (a transmembrane antibody). The antibody is modified via alternative splicing that adds a hydrophobic transmembrane domain and a short cytoplasmic domain (~3 aminoacids) at the C terminus of the immunoglobulin heavy chain (Wall Kuehl 1983). All naà ¯ve B cells only express both IgM and IgD classes of immunoglobulin but do switch to other classes upon activation by antigens (Goding, 1978). The antibody (figure 2C) is a highly specific Ig that can adopt any one of the 5 immunoglobulin isotopes, IgG, IgA, IgM, IgD and IgE. The antibody has 3 regions of which 2 regions (FAB) vary from antibody to antibody and bind to antigens and 1 region (FC) that binds to effector molecules. The antibody is composed of 2 light and 2 heavy chains held together by inter and intra disulphide bonds. The heavy chains depending on the Ig isotypes can be any one of ÃŽÂ ³, Ã⠀šÃ‚ µ, ÃŽÂ ±, ÃŽÂ ´ or Ɇº chains. The variable domains (VH and VL) bind to antigen and also bring about variability and antigen recognition specificity. This specificity is mainly due to the presence of 3 hypervariable regions (Complementary Determining Regions), namely CDR1, CDR2 and CDR3 in the variable regions. Similar to BCR, the antigen recognition medium in TCR is an immunoglobulin heterodimer made from ÃŽÂ ± and ÃŽÂ ² Ig chains (in most T cells) or ÃŽÂ ³ and ÃŽÂ ´ Ig chains. Unlike in BCRs where the IG can be of 5 types, in TCRs the Ig heterodimers are only of 2 types. The two Ig chains in TCRs are (also like BCRs) held together by intra and inter disulphide bonds. As seen in section C, each Ig chain folds into 2 domains, the variable and the constant domain. This folding greatly resembles the FAB region of the antibody in BCRs. Likewise antibodies, the ÃŽÂ ±ÃƒÅ½Ã‚ ² and ÃŽÂ ³ÃƒÅ½Ã‚ ´ heterodimers also have hypervariable regions (CDR1, CDR2 and CDR3) in variable domains. The variable regions in both BCRs and TCRs bring about specificity and diversity The BCR antibodies have a hinge joint (connecting FAB and FC) that makes the Ig molecule very flexible. Unlike antibodies, the flexibility of the TCR Ig molecule is very limited at the elbow region (junction of constant and variable region) (Degano et al, 1996). ii) ACCESSORY PROTEINS Both the BCR and TCR have very short cytoplasmic domains that restrict the binding of any signal transduction factors to the receptors. Due to this the receptors are unable to transducer signals into cells upon antigen recognition. Signal transduction is achieved via the accessory proteins. BCRs (figure 2 section A) accessory proteins consists of one or more dimmers of one each of Ig-ÃŽÂ ± and Ig-ÃŽÂ ² chains held together in the cell membrane by a pair of disulphide bonds. The cytoplasmic domains of these chains have phosphorylation sites called ITAMS. Unlike BCR accessory protein, the TCR accessory proteins (figure 2, section C) is composed of a complex know as CD3. It consists of 3 types of invariant chains, namely ÃŽÂ ³, ÃŽÂ ´ and Ɇº. A ÃŽÂ ³ or ÃŽÂ ´ chain couples up with one Ɇº chain (by formation of disulphide bonds) each to form two dimmers (ÃŽÂ ³Ãƒâ€°Ã¢â‚¬ º and ÃŽÂ ´Ãƒâ€°Ã¢â‚¬ º). In addition to this, a dimmer of 2 zeta (ÃŽÂ ¶) chains is also present. Together, these 3 dimers make up the CD3 complex. The ÃŽÂ ¶ chains have a much longer cytoplasmic tail than the ÃŽÂ ³, ÃŽÂ ´ and Ɇº chains and have 3 ITAMs as compared to one in the ÃŽÂ ³, ÃŽÂ ´ and Ɇº chains. Therefore for both BCR and TCR accessory proteins are dimmers that all contain ITAMs. B) GENERATION OF RECEPTOR DIVERSITY There are millions antigens and we need to produce millions of antibodies against them. However, we do not have millions of Ig genes so how are we able to produce all these different antibodies? The answer is antibodies are produced in developing B cells via genetic recombination of genes encoding the immunoglobulins (Hozumi and Tonegawa, 1976). The figure below shows the gene segments coding immunoglobulins. Figure legend: The human heavy chain locus as shown in the last row, consists of about 38-46 functional VH genes, 27 DH and 6 JH genes. The light chain can be either made of ÃŽÂ » or ÃŽÂ º chains. The ÃŽÂ » locus consists of about 30 functional V ÃŽÂ » genes and 5 J ÃŽÂ » genes each separated by a J segments. The Kappa locus has about 34-40 functional VÃŽÂ º genes and 5 JÃŽÂ º genes. The variable heavy chain region of the antibody is made from the joining of the V (variable), D (diversity) and J (joint) gene segments and the variable light chain (which can be either ÃŽÂ º or ÃŽÂ ») is formed from the joining of V and J segments only. A process called V(D)J recombination involves joining different gene segments and as a result bringing about antibody diversity. At the heavy chain locus, any one of the 27 D and 6 J gene segments are first joined together and then any one of 46 V gene segment is joined to this DJ segment. This rearranged DNA is then transcribed to form a primary mRNA. This mRNA then undergoes splicing to bring the VDJ segment close to the constant gene segment. Additional diversity is achieved as any 1 of the two types of light chains can be formed. Random insertion of nucleotides either side of D segments also creates N-nucleotide diversity. In total about 106 possible immunoglobulin gene combinations can be formed. This recombination process is driven by recombination signal sequences that flank the coding gene segments. Certain enzymes (RAG-1 and RAG-2) help mediate this somatic recombination process. The antibodies produce undergo a processs of clonal selectin where only the antibody specific to the antigen preferentially proliferates to make many antibodies. Binding affinity of BCR is greatly increased after antigen recognition where the variable regions of both heavy and light chain undergo somatic hypermutations. This is where point mutations are put in the variable regions of rapidly proliferating B cells. These mutations produce antibodies that may have good, moderate or good affinity for the antigens. The antibody with good affinity will have a selective advantage during clonal selection. The gene segements encoding TCR ÃŽÂ ² chain follow the similar V,D,J and C arrangement of BCRs. The recombination process involves of of the two DÃŽÂ ² genes rearranges next to one of JÃŽÂ ² genes. Then one of the ~50 V genes arranges next to the preformed DÃŽÂ ²JÃŽÂ ² genes. As seen , this is also similar to the B cells where a DJ segement forms first and then joins up with a V segment. There is also random insertion, just like in B cells, of nucleotides either side of D segments to create N-nucleotide diversity. Unlike in B cells, there is no somatic hypermutation in T cells after antigen recognition. If this occurs, the TCR will loose its ability to recognise MHC and the peptide it presents. C) ANTIGEN BINDING/RECOGNITION BCR and TCR have similar immunoglobulin antigen recognition receptors but the types of antigens they recognise are very different. BCR can recognise naÃÆ' ¯ve (as a whole) antigens and TCR can only recognise a single antigen peptide sequence presented onto cell surfaces by MHC (Major histocompatibility complex) molecules. The antigens recognised by B cells are naÃÆ' ¯ve and therefore the antibody in BCR mostly recognise discontinuous epitopes on the antigen and antigens recognised by the TCR is in form of linear peptide sequences and therefore they mostly recognise continuous or linear epitopes. Antigen recognition by BCR is very simple where the antibody variable region simply recognises specific epitopes on antigen and bind to it. The BCR can recognise 3 types of antigens, Type 1 thymus independent antigens (where bacterial lipoproteins can bind to mitogenic bypass molecules on B cells surface and this allows non-specific antigen B cell activation), Type 2 thymus independent antigens (appiles to antigens that have well spaced and repetitive polysaccharides that bind to multiple antibodies in BCR and activate the B cell) and Thymus dependent antigens (require helper T cells). Thymus dependent antigens when bind to TCR, instead of causing activation normally cause anergy. Due to this, once the binding has occurred, the whole antigen+TCR comples is endocytosed, the antigen is hydrolysed by enzymes and processed to small linear peptides and then presented onto the B cell surface via MHC2 molecules. Helper T cells then recognise this peptide-MHC complex. B cells have loads of C D40 on their surface that binds to CD40L present on Th helper cells. In response to this Th cells secrete IL-4, 5, 6 that also help activate other costimulatory molecules in the BCR coreceptor complex. All these events provide costimulation of the B cells and it is activated. ÃŽÂ ±ÃƒÅ½Ã‚ ² heterodimer TCRs in comparison can recognise any type of antigen that is processed and presented as a single peptide on MHC1 on target cells and MHC2 on B cells, macrophages and dendritic cells (all professional antigen presenting cells). The non-covalent forces that help TCR bind to the peptide-MHC complex are similar to the forces that enable the antibody bond to the antigen i.e. noncovalent. Unlike BCR that only have to recognise epitopes on antigens, the TCR has to both recognise the presence of both MHC molecule and antigen peptide. The TCR VÃŽÂ ± (variable alpha region) overlays ÃŽÂ ±2 helix of MHC1 or ÃŽÂ ²1 helix of MHC2 and the VÃŽÂ ² domain overlays ÃŽÂ ±1 helix in both MHC1/2. The CDR1 and CDR2 bind to ÃŽÂ ± helices of MHC and the CDR3 (which is more variable), binds to the antigen peptide on MHC. This concept is summarised in the picture below: Figure legend: The picture shows how the TCR variable complementarity determining regions (CDR) which are the binding sites interact with peptide-MHC complex. The CDR1 and CDR2 bind to the MHC alpha helices and CFR3 binds to the peptide. The ÃŽÂ ³ÃƒÅ½Ã‚ ´ TCRs are more similar to BCR antibody as they can recognise naÃÆ' ¯ve antigens without the requirement of processed antigen presentation. Another similarity of BCR and ÃŽÂ ³ÃƒÅ½Ã‚ ´ TCRs is that in the antibodies of BCRs, the CDR3 regions on heavy chain are shorter than the CDR3 in heavy chains and also the same in ÃŽÂ ³ÃƒÅ½Ã‚ ´ TCRs is seen where the ÃŽÂ ³ are shorter than the ÃŽÂ ´ CD3. COSTIMULATIONS Both lymphocytes do not get activated (but undergo anergy) once they recognise and bind to an antigen. They require costimulatory signals that will eventually lead to the activation of the lymphocytes. The B cells have BCR co receptor complex consisting of CD19 and CD21 (complement receptor), CD81 and LEU13 (interferon induced transmembrane protein 1). All these molecules are stimulated in presence of interferons and complements that give a costimulatory signal to B cells and activate it when it has recognised an antigen. The precise details of how these costimulatory molecules stimulate B cell signalling are still under investigation. In contrast to the 4 main costimulatory molecules in B cells, the primary costimulatory molecule in T cells is CD28 (figure besides) The binding of peptide-MHC to TCR causes up-regulation of certain molecules (e.g. CD28). T cells, like B cells can be costimulated by either cytokines or costimulatory molecule interactions. APC have surface molecules such as the B7.1 and B7.2 (or the CD80 and CD86) that recognise and bind to a molecule on the surface of the T cells called CD28 found on CD. This interacting provides co stimulation. The CTLA4 molecule is highly expressed after proliferation of the T cells. Once it binds to B7, instead of co stimulating T cells, it turns the T cells off. This is helpful in preventing excessive immune responses. No such regulatory mechanism is seen in B cells. A unique feature of T cells is that they have co receptors (CD4 and CD8) that help recognise the MHC molecules. CD4 molecules act as co receptors for MHC2 and are found on helper T cells and CD8 molecules present on cytotoxic T cells help recognise MHC1 molecules. ACTIVATION OF B AND T CELLS The activation of B and T cells following antigen recognition is somehow similar as it involves the phosphorylation of the ITAMS of accessory proteins. In B cells, antigen binding and co stimulation recruits the BCR+antigen to lipid rafts that brings protein tyrosine kinase Lyn close to the ITAMs of the cytoplasmic tails of the BCR associated proteins. Lyn phosphorylates ITAMs and triggers a signal cascade that results in increase of cytoplasmic calcium levels that activate transcription factors that control the entry of B cells into cell cycle. Eventually activate the B cells which then form plasma cells (that make loads of clones of antibodies to the antigen) and memory cells that will help manage subsequent infections. The initial proliferation of the activated B cell is accompanied by somatic hypermutation of the rearranged antibody variable genes that lead to the production of antibodies that may have poor, moderate or good binding capacity to the antigen. The good binding antib odies will be preferentially selected during clonal selection and they will further undergo proliferation to produce plasma and memory cells. A similar situation also occurs in T cells where there is activation of lipid rafts that bring the zeta chain ITAMS close to Lck (a protein tyrosine kinase) that phosphorylates the ITAMs and therefore create opportunity for other factors to bind to it and eventually cause mobilization of calcium that causes proliferation of T cell into Helper T cells, Regulatory T cells and Cytotoxic T cells.

Free Macbeth Essays: The Essential Macduff :: GCSE Coursework Macbeth Essays

The Essential Macduff in Macbeth Like in all (or most) Shakespeare plays, there is always a hero that overcomes evil supernatural forces. Macduff is this essential character in this play. His loyalty and patriotism to his dear country, Scotland, is more exceeding unlike the likes of the other Scottish nobles, Macduff was devastated by the murder of his dear king, and he also somewhat sacrifices his family for his country. These three transactions add up to one hell of an admirable hero. Conflict of forces is reflected in the character of Macduff. Duncan’s murder is discovered by his loyal supporter Macduff. It is the intensity of his devotion to the king that brings him to the castle just at the time of the murder and makes him the first to see the dead body, "The Lord’s anointed temple" (Act II, Scene3, 67) as he calls it. Had Macduff’s loyalty been supported by corresponding strength he could have come in time to save Duncan. But as Duncan displays goodness and virtue without sufficient power to maintain his rule, Macduff’s capacity for pure loyalty is not combined with the strength required to express it. When soon afterwards he goes to England in support of Duncan’s son Malcolm, his wife and children are left to be murdered by Macbeth. His personality lacks the energy to sustain both the commitments of his loyal heart. In expressing his loyalty to the dead king he ignores his equally great commitment to protect his family. Macduff returns from the scene of Duncan’s murder crying "O Horror, horror, horror!" (Act II, Scene3, 63) The response of the other lords is revealing. Lennox simply asks "Mean you his majesty?" (Act II, Scene3, 70), no more. The king’s sons arrive. Donalbain is silent. Malcolm says "O, by whom?" (Act II, Scene3, 100) Except for Macduff, there is no expression of horror, outrage or grief by those present. In the interview with Lady Macduff, Ross describes her husband as "noble, wise, judicious" (Act IV, Scene2, 16) one whom "best knows the fits o’ the season" (Act IV, Scene2, 17). Why then, did Macduff leave his wife and family unprotected? Perhaps, there was a conflict of loyalties in- love of country vs. love of family- in his heart; realist though he was, Macduff may not have believed that Macbeth would stoop to such brutality and wickedness as the murder of women and children.

Monday, August 19, 2019

A History Of Marriage And Divorce: Cohabitacion Can Result in a Positi

In the past fourteen billion years, the world has evolved numerous times. From creatures’ extinctions to the rise of technology, the world is constantly on a path of changes. And, even though not all events have been pleasant experiences, humans have definitely had the chance to learn from those happenings: one example being, marriage and its effects on family development. Since the beginning of time, open relationships between people, one reason being for the purpose of reproduction, have existed. It is simply part of human nature to bond with others; human instinct. History also shows that legal contracts did not tie up the first relationships during the Stone Age. However, due to society, marriage has been represented as the basis of a family, therefore, portraying that a legal contract amongst two heterosexual people is required in order to have the â€Å"happily ever after† story. But what happens when problems within a marriage exist, and the people involved are n o longer happy? What about those cohabitants who have gone through rough situations and still remain together for many years? So does a legal contract really determine the longevity of a marriage? What is the real definition of marriage? From the start of the Stone Age to current day, humans have witnessed the evolution of marriage, and the benefits of opting for cohabitation. The definition of marriage has gone from being a mandatory arrangement, to being part of the civil right movement, to cohabitation being the best or only alternative to marriage. Once humanity became civilized, the meaning of intercourse relationships went from it being a human instinct to a social requirement: â€Å"Apparently the single most important function of marriage throughout history has been... ... Moral Communities On Cohabitation.† Review Of Religious Research 54.1 (2012): 45- 67. Academic Search Premier. Web. 22 Apri. 2014. Kuby, William. â€Å"Making Marriage Work: A History Of Marriage And Divorce In The Twentieth-Century United States.† Journal Of American Culture 35.3 (2012): 279-280. Literary Reference Center. Web. 19 Apr. 2014. â€Å"Marriage.† Merriam-Webster. Merriam-Webster Incorporation, 2014. Web. 21 Apr. 2014. Murray, Melissa. â€Å"Marriage As Punishment.† Columbia Law Review. 112.1 (2012): 1-65. Academic Search Premier. Web. 20 Apr. 2014. Staub, August W. â€Å"Marriage, A History† Magill’s Literary Annual 2006 (2006): 1-3. Literary Reference Center. Web. 19 Apr. 2014. Stevenson, Betsey, and Justin Wolfers. â€Å"Marriage And Divorce: Changes And Their Driving Forces.† Journal of Economic Perspective 21.2 (2007): 27-52. Business Source Elite. Web. 20 Apr. 2014.

Sunday, August 18, 2019

Computers in the Classroom :: Technology School Essays

Computers in the Classroom Over the past decade the world has moved from a place with little digital technology to one where computers, video, and technology are used everyday. The use of this technology can not be ignored even in the classroom. It is impossible to live in o9ur world today without exposure to computers. As teachers it is part of our jobs to expose students to using computers at an early age and to incorporate technology into our lessons. During the middle school years using computers are a great way to get students excited about learning. It has even become mandatory as one of the NCTM (National Council for Teachers of Mathematics) standards. The technology principle states that technology helps students to fully understand mathematical concepts (Principles 25). They are great tools for any type of learner. The hands on experience helps the students to remember the concepts because they have something visual to reference (impact). The NCTM standards states, â€Å"Technology is essential in teaching and learning mathematics; it influences the mathematics that is taught and enhances students' learning† (Principles 25). As suggested, technology should not replace the traditional teaching strategies, but rather enhance them (impact). Many of the students know how to use the computers for fun things such as talking to their friends, playing games, and surfing the internet. However, few students know that computers can be used for educational things both inside and outside of the classroom. In math there are many ways to use computers in the classroom. One way to use computers in the classroom is by using online math games and manipulatives to help teach and review. In the class I am working with at Dunn Middle school they use games to help reinforce the lesson and to review for a test. During one review session before a test the students got into three groups one at each computer. They then logged onto the computers and played a fractions game. The students competed against each other for the most correct answers. All of the students were involved and enjoyed a break from the everyday instruction.

Saturday, August 17, 2019

Analyze Curriculum Foundations Essay

Choose one of the four foundations of curriculum (philosophical, historical, psychological, or social), and contrast its importance with the other three foundations. How does your selected foundation apply to your place of work/study? Charles Darwin; the father of speciation, stated in his book â€Å"On the Origin of Species† that the intelligence of mankind is merely the result of higher evolution. This theory is now being challenged by Marc Hauser, who is currently the director of cognitive evolution at Harvard University. In a recent article published in Scientific American, Hauser stated that humans possess four abilities that are not found in other species which are the essence of humaningueness. Those abilities are Generative Computation (the ability to generate limitless words and concepts), Promiscuous Combinations of ideas (the ability to merge different domains of knowledge), Mental Symbols (ways to encode sensory experiences), and Abstract Thought (the comprehension of things beyond what we can see). Each of these abilities are directly influenced by philosophical attributes, historical experiences, psychological behaviors, and social impacts (Wolchover). The purpose of this research is to examine and compare the importance of these influences in our educational system. Society has always been the driving force behind persuading Individuals behavior. When talking about curriculum it is the social factors of family, peers, idols, and teachers that possess the greatest ability of manipulating our young people today. The family will infuse its beliefs or morals onto its members. For example; if the parents of a family are uneducated and working low income jobs, education may not be their primary concern. Instead their interest may shift to basic needs, such as bringing more income into the house as soon as possible. That usually reflects a negative outlook on education. In turn the student will be unable to receive adequate help form their parents on school work. In hindsight; if both parents are highly educated, they will place greater infuses on academics. Their expectation in their children’s education becomes much higher. Peers and Idols have a hypnotic like hold on our young people and harness the power to undermine even the most stable of families. The desire to be accepted can be overwhelming to most. Some teenagers turn to idolizing rappers, TV stars, or sport figures in hopes of being recognized. The artist that are choosing; usually defies the law and express little to no morals towards women, society, and puts no value on education. We can see this today in our young people, with the sagging paints, rebelling attitudes, belittling female, fathering multiple children from as many women as possible and leaving the mothers to take care of the children. This type of behavior has become very desirable. There is no doubt that society has a hold on forming the behavior of our young people, but it is the psychological need to bradding or concepts of life. This concept may go by many names such as self-actualization or individuation. No matter what you call it, it is a natural drive within the human psychic to behave in a manner that is coherent to one self. Educational Psychology focuses on how children learn. A lot of research has gone into this field of study. It tries to answer questions like how effective is intervention, how should a room be set up for opium learning, how should lessons be taught, and how students learn and develop overall. As you can see this this discipline is concerned with the mindset of the students; what they are feeling, how they see or perceive situations. This is an attempt to put the students at ease by feeling safe and understood. To succeed this field of study must incorporate the social factors of the students in that area. Without understanding their social needs or wants any efforts are predetermined to fail. Philosophy on the other hand applies the directions for teachers to follow. It tells parents and students how teacher or school intends to treat them. The schools philosophy might instruct teachers on how to give a lesson or what order to teach their subjects. An example of this might insist that each student must make a passing grade before the teacher is allowed to advance the class to another topic or tell a biology teacher that he or she will have to teach cell functions before teaching Mendel’s genetics. The Schools philosophy statement might read something like this; our school believes that all students are unique individuals that deserve a safe secure place that will nurture them emotionally as well as intellectually. Provide a place that would escalate their potential to new highs and promote respect towards family, school and society, but a teachers philosophy would be more geared for his or her room. Over all the philosophy in curriculum provides guidance, a way of doing things, and opinions on how students should be treated. This type of discipline requires the knowledge of the communities believes, economic status, and the desires of the parents for their children. Like psychological behaviors; it has to take in account the social attributes of its population. Around the nineteenth century public schools were set up to promote reading, writing, and arithmetic. These were the skills needed to hold a job. Subjects like biology, civics, world history or health were unimportant to the public schools and was reserved for private schools whose students were being groomed for universities. The welfare of the student’s character or moral values where of no concern to the schools at this time. Only recently have the schools shifted to developing the entire student’s well-being. Focusing more on what it takes to produce a well-round individual which has the ability to rationalize complex situations and develop into a productive member of society. This is achieved by teaching all core subjects not ju st a select few. To succeed the schools have to put real-world applications to old-world disciplines. Today all public schools would like to see every student attend some kind of institute for higher learning. Today’s institutes of learning will incorporate psychology (a natural drive within the human psychic to behave in a manner that is coherent to one self, set up parameters for teachers curriculum), Philosophy (tells parents and students how teacher or school intends to treat them and what they are willing to provide), historical ( brought about the intergrading of core classes, set a pace on when a student is ready to advance to more complex subjects), and they have to take into consideration the social influences of the families, peers, as well as the community if they are to form a working curriculum. The curriculum should be an organized process that promotes a more student centered approach to learning, by directing the course of study in such a manner that it challenges the student at a constant upgrade in levels of difficulty which allows the student to comprehend a nd utilize pass lessons or experiences and promote individualization within the society. I have been teaching middle school biology for eight years now and we have to follow certain guidelines that make up our curriculum. It all starts with the entrance of the room. It must be inviting and shouts out come see. Once in the room they have to feel safe and comfortable. This room has to become their safe haven, where all the pressures of home and peers become nonexistence. I have to develop all aspects of the student’s life. Not only does this involve the core classes, but it could involve maturity levels, self-confidence, behavior problems, and social interactions. The class subject has to be taught according to the State of Alabama’s Board of Education. I am given a set of standards each year and must cover each one to mastery. My lessons have to meet every students learning style, and treat every student as an individual with different needs and goals. Every lesson has to have three parts a beginning (this must capture the students interest and be a prelude to that days topic), during (this is the meat and potatoes of the lesson, this could range from reading text to given lectures and everything in between. In this section of the lesson the objectives for that day must be met), and finally the after part of the lesson ( this is where the students have to show me that they were able to comprehend that days objectives and it gives me a chance to analyze my delivery of the subject matter). Before the curriculum can have any effect on the students I have to get to know them. I need to understand how they live and what they want out of life. This will allow me to teach in a manner that relates to them. It will give my lessons value and a means to an end. As you can tell all the disciplines are incorporated into every lesson. For this system to work all teachers have to look beyond the course of study and take more interest into the stu dents. References Natalie Wolchover, Life’s Little Mysteries Staff Writer (What Distinguishes Humans from Other Animals?) 03 July 2011 Time: 09:21 AM ET

Friday, August 16, 2019

Ethno Linguistic Group

Heruela, Christine Mae O. BSMA-4 13 Muslim Ethno Linguistic Groups 1. Maguindanao Maguindanao originally means â€Å"people of flooded plain. † The name Maguindanao was also named after the Sultanate or dynasty that ruled the area for several years. People living in the Pulangi area, located in what are now North Cotabato, Sultan Kudarat and Maguindanao Provinces. Cultural communities within this region also include the Tituray, T'boli and the Manobos. 2. Maranao Maranao means â€Å"people of the lake. † Their homeland is called Lanao or â€Å"lake. Their oldest settlement started around here, and up to this day, highly populated communities still dot the lake. Their language is similar to Maguindanaon and Iranun. The Maranao form the largest Muslim community and cultural minority in the Philippines. Their families are traditionally large and close-knit. Feudal standing is in some parts still visible. The position, wealth and land ownership of many of those considered from an ancestry of â€Å"royalty† still maintain some political position or prominence in their areas. Most devout and most traditional of the Muslim communities.They have braved much of the attempts to conquer and subdue them. They are also known for their artistry in carving, boat making and creation of malongs. 3. Tausug â€Å"Tausug† derives from tau meaning â€Å"man† and sug meaning â€Å"current† and translates into â€Å"people of the current. † Another argument made on the meaning of the name states that the name in fact translates to â€Å"brave people†. The Tausug even before the arrival of Islam or Christianity and the people who promulgated their system of government, the Sulu Islands, where the Tausugs are found, had their own system of government.The Tausugs openly welcomed Islam and the system of government that came with it. This has bred to the establishment of the Sulu sultanate. Leaders from this region moved to other pl aces in the country, spreading Islam and its system of government in Tawi-Tawi, Palawan, Basilan, Zamboanga, and Sabah. 4. Sama Also in the Sulu Archipelago are the Sama consisting of five sub-groups including the Sama! and the Badjao. These people are highly dispersed in the Sulu Archipelago. They are considered boat-people, spending most of their time in constant movement throughout the islands in the area or living on the water.The Sama are also considered the sea-gypsies of the Philippines. The Sama people groups are generally referred to in Sabah as the East Coast Bajau. The government does not distinguish one Bajau group from the other. While outsiders call them Bajau, they most commonly refer to themselves as Sama. 5. Yakan Yakan is the majority Muslim group in Basilan and some in Zamboanga. The Yakan have generally two spheres of belief integrating Islamic principles and traditional beliefs into what is referred to as â€Å"folk Islam†. There is little known about thi s people.One of the highlights of their history is the arrival of Pedro Cuevas or Datu Kalun, an outsider who killed the datu of the Yakan and then was accepted as their Datu in the early 1800. The Yakans were primarily under the Sulu Sultanate, but proving to be deliberately their own through the leadership of Datu Kalun, the Basilan Yakan had given the Spanish and Americans. However, the Yakan have remained in many instances separate from any rule, other than that of Sultanates their Datu follows. Due to much political conflict in the area of Basilan, many of the Yakans have settled in the region of Zamboanga City. . IIanon or Iranun The lranun are said by many to have been the origin of the ethnic groups within the Lanao del Sur to the Maguindanao areas. The Iranun language is in fact seen in the Maranao and Maguindanao languages. The Iranun were said to have fought under the Maguindanao sultanate. Many sultans of Maguindanao were said to have been from the lranuns. 7. Molebugan or Molbog The Molbog mostly live in Bafabak, Palawan. The word molbog originated from the word â€Å"malubog† which means â€Å"murky or turbid water†. Their language and practices share close affinity to the Orang Tidung (Sabah), Sama and the Tausugs.These people and other Muslim communities in Palawan were ruled by Sulu datus under the Sulu sultanate. 8. Kolibugan Kolibugan means â€Å"half-breeds. † Originally from the Subanon tribes, these people are called such because their culture has been said to be half breed, having come into Islam through intermarriage with Muslim communities. These people live the Subanun organization and language. The term  kolibugan  is as well used to refer to all peoples who have accepted Islam through intermarriage. 9. Sangil The Sangil are found in the Balut Sarangani, parts of South Cotabato and Davao Del Sur provinces.They are said to have come from Sanghe (islands in Indonesia between the Celebes), the origin of the name Sangil. Their name is derived from Sanghe, refering to an archipelago in eastern  Indonesia  located between Sulawesi (Celebes) and  Mindanao  which pertains to the original home of the Sangil. They are people who were already Muslims before they came to Philippine shores. The Sangil are also known for their boat making. They have also been said to be the buccaneers who attacked Spanish territories in other parts of the Philippines. 0. Kalagan Kalagan was derived from the word kaag, which meant â€Å"whisper. †The Kaagan are mostly found in the  Davao  provinces. Their islamization was achieved through the arrival of the Maguindaon and the Tausug. However, when the Maguindanao sultanate and Tausug left, the Kaagan became marginalized and with less improvement in their social organization. 11. Palawanon Palawan inhabitants (Panimusan) were islamized through the Sulu sultanate, through the Tausug who went there to introduce to Islam to the local people.Now, the Mus lim populations in the area are found in Batarasa, Quezon, Brooke's Point, Espanola, Narra, Roxas, Taytay and Aborlan. 12. Badjao Scattered throughout the Sulu Archipelago of the Philippines live the Sama Badjao, a people nobody wants. Badjao means â€Å"man of the seas. † By tradition, the people are sea nomads, traveling by boat from one island to the next in search of a fishing harvest. But the Sama Badjao are known to other tribes living in the same area as ‘palau' or ‘lumaan,' both meaning â€Å"godforsaken. †Ã‚   13.Jama Mapun The Jama Mapun or literally â€Å"people of Mapun,† occupy the island of Cagayan de Sulu in southwestern Philippines. They call their island Tana (land) Mapun and their language, Pullum Mapun. The Jama Mapun are closely related to the Samal, and they are often referred as to the Samal Cagayan by the Tausog of Sulu or as the Samal Cagayan by the Tausog of Sulu or as the Badjao or Orang Cagayan by the coastal Muslim of Born eo. The Jama Mapun can also be found in the islands of Bugsuk, and the small island in between.